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US 2025/0074889 A1Published application
Novel Aminobenzene Derivative Having Cancer Cell Growth Inhibitory Effect, and Preventive or Therapeutic Pharmaceutical Composition Containing Same as Active Ingredient
AssigneeDaewoong Pharmaceutical Co., Ltd.
InventorsYoungku Kang, Inyoung Lee, Bora Yoo, Ji Duck Kim, Youngwoo Choi, Sujin Ha, Ahreum Kwon, Joon Seok Park
Life of this patent
Estimating the term…
Abstract
A compound represented by Chemical Formula 1 or 2 of the present invention, or a pharmaceutically acceptable salt thereof can be used favorably for preventing or treating cancer or tumors.
Claims15
A compound represented by the following Chemical Formula 1 or 2, or a pharmaceutically acceptable salt thereof:
- in Chemical Formulas 1 and 2,
- L1 is a single bond, a C1-6 alkylene, a C2-4 alkenylene, or a C2-4 alkynylene,
- R1 is phenyl, or a 5- or 6-membered heterocycle containing 1 to 4 heteroatoms each independently selected from the group consisting of N, O and S,
- the R1 is unsubstituted or substituted with halogen, a C1-4 alkyl, a C1-4 thioalkyl, a C1-4 haloalkyl, a C1-4 alkoxy, a C1-4 thioalkoxy, a C1-4 haloalkoxy, a C2-4 alkenyl, a C2-4 alkynyl, a C3-6 cycloalkyl, amino, nitro, cyano, a (C1-4 alkyl)amino, or a di(C1-4 alkyl)amino,
- R2 is —N(R9)—L2-R5,
- L2 is a single bond, a C1-6 alkylene, a C2-4 alkenylene, or a C2-4 alkynylene,
- R5 is a C3-7 cycloalkyl, phenyl, or a 5- or 6-membered heteroaryl containing 1 to 4 heteroatoms each independently selected from the group consisting of N, O and S,
- the R5 is unsubstituted or substituted with 1 to 3 substituents each independently selected from the group consisting of hydroxy, halogen, a C1-4 alkyl, a C1-4 alkoxy, a C1-4 haloalkyl, a C1-4 haloalkoxy, a C1-4 thioalkyl, and a C3-6 cycloalkyl,
- each R6 is independently hydrogen, halogen, a C1-6 alkyl, a C1-6 haloalkyl, a C1-6 alkoxy, or a C3-7 cycloalkyl,
- R9 is hydrogen, halogen, a C1-4 alkyl, a C1-4 alkoxy, a C1-4 haloalkyl, a C1-4 haloalkoxy, or a C3-6 cycloalkyl,
- each R3 is independently hydrogen, halogen, a C1-6 alkyl, a C1-6 haloalkyl, or a C1-4 alkoxy,
- each R4 is independently hydrogen, a C1-4 alkyl, —CH2N(R7)2, or a 5- or 6-membered heteroaliphatic ring containing one or two N which is substituted with R7,
- each R7 is independently hydrogen, or a C1-4 alkyl,
- X is CR8, or N,
- R8 is hydrogen, or halogen, and
- Y is CO, CS, or SO2.
13 more elements
(canceled)
Dependencies are inferred from the claim text.