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US 2025/0072405 A1Published application
Genetically Modified Non-Human Animals And Methods Of Use Thereof
AssigneesRegeneron Pharmaceuticals, Inc., Yale University, Institute for Research in Biomedicine (IRB)
InventorsRichard Flavell, Markus Manz, Anthony Rongvaux, Till Strowig, Tim Willinger, Andrew Murphy, Sean Stevens, George Yancopoulos
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Abstract
The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.
Claims21
-27. (canceled)
A mouse embryonic stem(ES) cell, comprising:
- a nucleic acid encoding a human M-CSF polypeptide operably linked to a promoter;
- a nucleic acid encoding a human IL-3 polypeptide operably linked to a promoter;
- a nucleic acid encoding a human GM-CSF polypeptide operably linked to a promoter;
- a nucleic acid encoding a human SIRPα polypeptide operably linked to a promoter;
- and
- a nucleic acid encoding a human TPO polypeptide operably linked to a promoter.
3 more elements
A mouse embryonic stem(ES) cell, comprising:
- a nucleic acid encoding a human M-CSF polypeptide operably linked to a promoter;
- a nucleic acid encoding a human IL-3 polypeptide operably linked to a promoter;
- a nucleic acid encoding a human GM-CSF polypeptide operably linked to a promoter;
- and
- a nucleic acid encoding a human TPO polypeptide operably linked to a promoter.
2 more elements
Dependencies are inferred from the claim text.