Rhenium(V) Alkylidyne Complexes and Methods of Use and Preparation Thereof
AssigneeThe Hong Kong University of Science and Technology
InventorsGuochen JIA, Mingxu CUI, Jie HUANG
Life of this patent
Estimating the term…
Abstract
Re(V) alkylidyne-based catalytic systems for alkyne metathesis reactions capable of effecting alkyne metathesis, such as homo- and cross-metathesis of alkynes or diynes, ring closing metathesis and ring-opening metathesis, at room temperature to moderate temperatures. The catalysts are stable to air and moisture and tolerate a variety of functional groups in substrates and can be readily prepared on a large scale, and thus are practical catalytic systems of Re(V) alkylidynes.
Claims20
A rhenium(V) alkylidyne complex of Formula 1:
- wherein L is H2O, an ether, a ketone, a furan, a thioether, a thiophene, a tertiary amine, or a metal salt selected from the group consisting of a metal halide, a metal alkoxide, a metal thiolate and a metal amide
- R is alkyl, aryl, thiophene, or CH2Ari, wherein Ar1 is aryl;
- each of R4 and R5 is independently alkyl, cycloalkyl or aryl;
- and
- R6 for each instance is independently alkyl, alkenyl or aryl.
A method for performing a metathesis reaction, the method comprising:
- contacting a catalyst precursor of Formula 2, a phosphine scavenger, and at least one alkyne substrate thereby forming an alkyne metathesis product, wherein the catalyst precursor of Formula 2 has the structure:
- wherein R is alkyl, aryl, thiophene, or CH2Ar1, wherein Ar1 is aryl;
- PR′3 is PMePh2 or PMe2Ph;
- each of R4 and R5 is independently alkyl, cycloalkyl, or aryl;
- and
- R6 for each instance is independently alkyl, alkenyl or aryl;
- and
- the phosphine scavenger is selected from [(p-cymene]RuCl2]2, [(p-cymene]OsCl2]2, [RhCl(COD)]2, IrCl(COD)]2, PdCl2(COD), CuCl, or CuI.
Dependencies are inferred from the claim text.