Optimal multi-electrode transcutaneous stimulation with high focality and intensity
AssigneeThe Regents of the University of California
InventorsYing Li, Wentai Liu, Yi-Kai Lo
Life of this patent
Estimating the term…
Abstract
Methods, apparatus, and systems are disclosed for optimization techniques and a realistic 3D model to design optimal parameters for transcutaneous stimulation to achieve focalized stimulation of a target tissue such as the spinal cord, brain or other internal organ. The methods, apparatus, and systems include generation of a 3D model from a CT/MRI image, as well as an optimization algorithm that enables stimulation of any target location (e.g., on the dorsal root, or on the dorsal column) with any orientation at high precision.
Claims21
1-16. (canceled)
A system comprising:
- a stimulation array comprising multiple stimulation electrodes arranged in an array;
- a stimulator circuit configured to provide independent stimulation signals to individual electrodes in the stimulator electrode array at a plurality of frequencies, intensities, and/or waveforms, wherein the independent stimulation signals are configured to modulate spinal cord circuits to improve/recover at last a portion of a network;
- an external device comprising:
- a non-transitory memory storing instructions, and
- a processor configured to access the non-transitory memory and execute the instructions to at least:
- receive one or more structural images of a target treatment region of a patient when the stimulation array is placed within the target treatment region;
- generate a model of the target treatment region when the stimulation array is placed within the target treatment region based on the one or more structural images of the target treatment region;
- determine a safety limit for transcutaneous stimulation of the target treatment region;
- generate a set of stimulation parameters for a stimulation to be delivered by the multiple stimulation electrodes based on a lead field matrix, associated with the stimulation electrode array and the target treatment region, and the safety limit;
- and
- configure the stimulator circuit to operate utilizing the generated set of stimulation parameters to deliver the stimulation with the set of stimulation parameters to the patient transcutaneously.
A method comprising:
- recording and/or monitoring, by a system comprising a processor, at least one brain signal of a patient;
- generating, by the system, a set of stimulation parameters for a stimulation based on the at least one brain signal of the patient;
- selecting, by the system, at least one electrode in an electrode array to deliver the stimulation to a location in the patient's spinal cord based on the at least one brain signal of the patient;
- and
- sending, by the system, the stimulation to the at least one electrode in the electrode array.
A system comprising:
- at least one input configured to receive one or more signals related to regulation of a patient's autonomic system;
- and
- a controller comprising a memory and a processor configured to execute instructions to adapt a neurostimulation based on the one or more signals received by the at least one input.
Dependencies are inferred from the claim text.