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AssigneeAllen Institute
InventorsThomas F. BUMOL, Xiao-Jun LI, Adam SAVAGE, Peter SKENE, Troy TORGERSON, Suhas VASAIKAR
Estimating the term…
Provided herein are methods, devices, and systems comprising identification of a panel of gene markers useful for immune cell typing and identifying, detecting, and/or monitoring disease conditions in a subject in need thereof, including infections, cancer and autoimmune conditions. The methods also provide for assays for determining the levels of said markers prior to and after treatment of a condition in the subject, wherein the condition is impacted by one or more factors including age, occupation or environment of the subject.
A method of identifying, detecting, and/or monitoring a health condition in a subject in need thereof, comprising measuring levels of a set of genes in a biological sample obtained from the subject, wherein the set of genes comprises all or a subset of A1BG, ABLIM1, AC020656.1, AC243960.1, ADTRP, AFF3, ALDH2, ANXA2R, APOBEC3C, APP, AQP3, ARID5B, ATF7IP2, BANK1, BCL11A, BCL11B, BIRC3, BLK, CAMK4, CAPG, CARS, CASP8AP2, CBL, CCDC167, CCDC50, CCL4, CCND2, CCR7, CD14, CD27, CD36, CD6, CD68, CD79A, CD79B, CD8A, CD8B, CD96, CDKN1C, CEBPD, CFD, CFP, CLEC10A, CLEC12A, CLIC3, CMC1, CPVL, CSF3R, CST7, CSTA, CTSH, CXXC5, CYBB, CYTOR, DCTPP1, DNAJB1, DOK2, DYNLL2, DYRK2, EAF2, EBP, ERN1, FCER1A, FCER1G, FCER2, FCGR3A, FCN1, FCRL1, FGFBP2, FGL2, FHIT, FKBP11, GATA3, GBP5, GIMAP7, GNG2, GPR65, GRN, GZMA, GZMB, GZMH, GZMK, HLA-DMA, HLA-DMB, HLA-DQA1, HOPX, IFITM3, IFT57, IGHD, IGHM, IGLC2, IGSF6, IKZF3, IL2RB, IL3RA, IL4R, IL6ST, INPP4B, IRF7, IRF8, ITGAL, ITM2C, JAML, JCHAIN, JUN, KLRB1, KLRC1, KLRD1, KLRF1, KLRG1, LEF1, LGALS2, LGALS3, LILRA4, LINC00623, LINC00861, LINC00926, LINC01857, LINC01871, LINC02446, LRRC25, LY86, LYN, LYST, MAL, MAML2, MAPKAPK2, MARCHF1, MARCKS, MATK, MEF2C, MHENCR, MNDA, MS4A1, MS4A6A, MS4A7, MT1X, MYBL1, MYC, MYO1F, MZB1, NCF2, NCR3, NELL2, ORAI2, OXNAD1, PAG1, PASK, PDE3B, PDLIM1, PECAM1, PHACTR2, PIK3IP1, PILRA, PITPNC1, PLD4, PLPP5, POU2AF1, POU2F2, PPP1 R10, PRF1, PRKCH, PRR5, PTPN4, PTPN6, PYHIN1, RALGPS2, RASSF1, RCAN3, RFLNB, RHOC, RNF130, RTKN2, S100A12, S100B, SAMD3, SELENOM, SERPINA1, SERPINF1, SESN3, SLC2A4RG, SLC4A10, SMIM25, SP140, SPI1, SPIB, SPON2, STMN1, STMN3, STX7, SWAP70, SYNE1, TAGAP, TBC1D15, TC2N, TCF4, TCL1A, THEM4, TMEM154, TMEM156, TMIGD2, TNFRSF13C, TNFRSF1B, TPD52, TPM2, TPST2, TRABD2A, TRDC, TRG-AS1, TRGC1, TRGC2, TSHZ2, TSPAN3, TULP4, UGCG, VCAN, XCL1, XCL2, ZAP70, and ZEB2.
A method of identifying, labeling, and/or quantifying immune cell types in a biological sample, comprising measuring levels of a set of genes in the biological sample, wherein the set of genes comprises all or a subset of A1BG, ABLIM1, AC020656.1, AC243960.1, ADTRP, AFF3, ALDH2, ANXA2R, APOBEC3C, APP, AQP3, ARID5B, ATF7IP2, BANK1, BCL11A, BCL11B, BIRC3, BLK, CAMK4, CAPG, CARS, CASP8AP2, CBL, CCDC167, CCDC50, CCL4, CCND2, CCR7, CD14, CD27, CD36, CD6, CD68, CD79A, CD79B, CD8A, CD8B, CD96, CDKN1C, CEBPD, CFD, CFP, CLEC10A, CLEC12A, CLIC3, CMC1, CPVL, CSF3R, CST7, CSTA, CTSH, CXXC5, CYBB, CYTOR, DCTPP1, DNAJB1, DOK2, DYNLL2, DYRK2, EAF2, EBP, ERN1, FCER1A, FCER1G, FCER2, FCGR3A, FCN1, FCRL1, FGFBP2, FGL2, FHIT, FKBP11, GATA3, GBP5, GIMAP7, GNG2, GPR65, GRN, GZMA, GZMB, GZMH, GZMK, HLA-DMA, HLA-DMB, HLA-DQA1, HOPX, IFITM3, IFT57, IGHD, IGHM, IGLC2, IGSF6, IKZF3, IL2RB, IL3RA, IL4R, IL6ST, INPP4B, IRF7, IRF8, ITGAL, ITM2C, JAML, JCHAIN, JUN, KLRB1, KLRC1, KLRD1, KLRF1, KLRG1, LEF1, LGALS2, LGALS3, LILRA4, LINC00623, LINC00861, LINC00926, LINC01857, LINC01871, LINC02446, LRRC25, LY86, LYN, LYST, MAL, MAML2, MAPKAPK2, MARCHF1, MARCKS, MATK, MEF2C, MHENCR, MNDA, MS4A1, MS4A6A, MS4A7, MT1X, MYBL1, MYC, MYO1F, MZB1, NCF2, NCR3, NELL2, ORAI2, OXNAD1, PAG1, PASK, PDE3B, PDLIM1, PECAM1, PHACTR2, PIK3IP1, PILRA, PITPNC1, PLD4, PLPP5, POU2AF1, POU2F2, PPP1R10, PRF1, PRKCH, PRR5, PTPN4, PTPN6, PYHIN1, RALGPS2, RASSF1, RCAN3, RFLNB, RHOC, RNF130, RTKN2, S100A12, S100B, SAMD3, SELENOM, SERPINA1, SERPINF1, SESN3, SLC2A4RG, SLC4A10, SMIM25, SP140, SPI1, SPIB, SPON2, STMN1, STMN3, STX7, SWAP70, SYNE1, TAGAP, TBC1D15, TC2N, TCF4, TCL1A, THEM4, TMEM154, TMEM156, TMIGD2, TNFRSF13C, TNFRSF1B, TPD52, TPM2, TPST2, TRABD2A, TRDC, TRG-AS1, TRGC1, TRGC2, TSHZ2, TSPAN3, TULP4, UGCG, VCAN, XCL1, XCL2, ZAP70, and ZEB2.
A single cell assay kit comprising probes for measuring levels of a set of genes in a biological sample, wherein the set of genes comprises all or a subset of A1BG, ABLIM1, AC020656.1, AC243960.1, ADTRP, AFF3, ALDH2, ANXA2R, APOBEC3C, APP, AQP3, ARID5B, ATF7IP2, BANK1, BCL11A, BCL11B, BIRC3, BLK, CAMK4, CAPG, CARS, CASP8AP2, CBL, CCDC167, CCDC50, CCL4, CCND2, CCR7, CD14, CD27, CD36, CD6, CD68, CD79A, CD79B, CD8A, CD8B, CD96, CDKN1C, CEBPD, CFD, CFP, CLECI0A, CLECI2A, CLIC3, CMC1, CPVL, CSF3R, CST7, CSTA, CTSH, CXXC5, CYBB, CYTOR, DCTPP1, DNAJB1, DOK2, DYNLL2, DYRK2, EAF2, EBP, ERN1, FCER1A, FCER1G, FCER2, FCGR3A, FCN1, FCRL1, FGFBP2, FGL2, FHIT, FKBP11, GATA3, GBP5, GIMAP7, GNG2, GPR65, GRN, GZMA, GZMB, GZMH, GZMK, HLA-DMA, HLA-DMB, HLA-DQA1, HOPX, IFITM3, IFT57, IGHD, IGHM, IGLC2, IGSF6, IKZF3, IL2RB, IL3RA, IL4R, IL6ST, INPP4B, IRF7, IRF8, ITGAL, ITM2C, JAML, JCHAIN, JUN, KLRB1, KLRC1, KLRD1, KLRF1, KLRG1, LEF1, LGALS2, LGALS3, LILRA4, LINC00623, LINC00861, LINC00926, LINC01857, LINC01871, LINC02446, LRRC25, LY86, LYN, LYST, MAL, MAML2, MAPKAPK2, MARCHF1, MARCKS, MATK, MEF2C, MHENCR, MNDA, MS4A1, MS4A6A, MS4A7, MT1X, MYBL1, MYC, MYO1F, MZB1, NCF2, NCR3, NELL2, ORAI2, OXNAD1, PAG1, PASK, PDE3B, PDLIM1, PECAM1, PHACTR2, PIK3IP1, PILRA, PITPNC1, PLD4, PLPP5, POU2AF1, POU2F2, PPP1R10, PRF1, PRKCH, PRR5, PTPN4, PTPN6, PYHIN1, RALGPS2, RASSF1, RCAN3, RFLNB, RHOC, RNF130, RTKN2, S100A12, S100B, SAMD3, SELENOM, SERPINA1, SERPINF1, SESN3, SLC2A4RG, SLC4A10, SMIM25, SP140, SPI1, SPIB, SPON2, STMN1, STMN3, STX7, SWAP70, SYNE1, TAGAP, TBC1D15, TC2N, TCF4, TCL1A, THEM4, TMEM154, TMEM156, TMIGD2, TNFRSF13C, TNFRSF1B, TPD52, TPM2, TPST2, TRABD2A, TRDC, TRG-AS1, TRGC1, TRGC2, TSHZ2, TSPAN3, TULP4, UGCG, VCAN, XCL1, XCL2, ZAP70, and ZEB2.
Dependencies are inferred from the claim text.