Methods for detecting or treating influenza infections
AssigneeThe University of Chicago
InventorsJenna GUTHMILLER, Patrick WILSON
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Abstract
To address the need in the art, the inventors have comprehensively characterized Aspects of the disclosure relate to novel antibody and antigen binding fragments. Further aspects relate to polypeptides comprising the antigen binding fragment(s) of the disclosure, and compositions comprising the polypeptides, antibodies, and/or antigen binding fragments of the disclosure. Also described are nucleic acids encoding an antibody or antigen binding fragment of the disclosure.
Claims64
An antibody or antigen binding fragment comprising a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises a HCDR1, HCDR2, and HCDR3 having at least 80% sequence identity to the HCDR1, HCR2, HCR3 from a heavy chain variable region encoded by the heavy chain nucleic acid of an antibody clone of Table 1 and wherein the light chain variable region comprises a LCDR1, LCDR2, and LCDR3 having at least 80% sequence identity to the LCDR1, LCDR2, and LCDR3 from the light chain variable region encoded by the light chain nucleic acid of the same antibody clone of Table 1.
A nucleic acid encoding an antibody heavy chain, wherein the nucleic acid has at least 70% sequence identity to a heavy chain nucleic acid of Table 1.
A nucleic acid encoding an antibody light chain, wherein the nucleic acid has at least 70% sequence identity to a light chain nucleic acid of Table 1.
Dependencies are inferred from the claim text.