Il-4 derived peptides for use in the treatment of obesity

A peptide or a pharmaceutically acceptable salt thereof for use in the treatment of obesity, wherein the peptide is a dimer comprising two fragments, each fragment consisting of 13 to 19 contiguous amino acid residues derived from the amino acid region AA71-AA94 of interleukin-4 (SEQ ID NO:4) (i.e. the α-helix C of IL-4), or a variant thereof having one, two, three, or four amino acid substitutions, wherein the two fragments are covalently linked through a linker and wherein the peptide is an agonist on type I IL-4R and an antagonist on type II IL-4R, and further wherein at least part of the peptide forms an α-helix.

A peptide or a pharmaceutically acceptable salt thereof for use in the treatment of obesity, wherein the peptide is a dimer comprising two fragments, wherein the peptide has the structure of the Formula (I):

• or is a variant thereof having one substitution in each peptide fragment.