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AssigneeIndustry-Academic Cooperation Foundation, Yonsei University
InventorsHeon Yung GEE, Hyun Woo PARK, Jongwook OH, Yujin SUB
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The present invention relates to the discovery of an agent for measuring the expression level of a protein that induces the acquisition of metastatic ability by tumor cells, or a gene encoding the same, and a method for preventing or treating metastatic cancer by controlling the expression of the protein or gene. The present invention provides effective biomarkers for metastatic cancer that are capable of significantly improving the patient's survival rate when detected early, and provides a method capable of predicting with high reliability the likelihood that primary cancer will progress to metastatic cancer. Thus, the present invention may be useful for efficient prevention or treatment of metastatic cancer by inhibiting the expression of these factors.
1-11. (canceled)
A method for diagnosing metastatic cancer, the method comprising measuring an expression level of at least one protein selected from the group consisting of IKZF1 (Ikaros Transcription Factor 1), IKZF3 (Ikaros Transcription Factor 3), NFE2 (Nuclear Factor, Erythroid 2), and IRF8 (Interferon Regulatory Factor 8), or a gene encoding the protein.
A method for providing information necessary for diagnosing metastatic cancer, the method comprising a step of measuring an expression level of at least one protein selected from the group consisting of IKZF1, IKZF3, NFE2, and IRF8, or a gene encoding the protein, in a biological sample isolated from a subject.
A method for preventing or treating metastatic cancer, the method comprising administering, as an active ingredient, a composition comprising an inhibitor of at least one selected from the group consisting of IKZF1, IKZF3, NFE2, and IRF8 to a subject in need thereof.
A method for screening a composition for preventing or treating metastatic cancer, the method comprising steps of:
Dependencies are inferred from the claim text.