US 2025/0051326 A1 · CRYSTALLINE FORMS OF CFTR MODULATORS

Crystalline forms of cftr modulators

AssigneeVertex Pharmaceuticals Incorporated

InventorsYi Shi, Kevin J. Gagnon, Jicong Li, Jennifer Lu, Ales Medek, Muna Shrestha, Michael Waldo, Beili Zhang, Carl L. Zwicker, Corey Don Anderson, Jeremy J. Clemens, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Peter Grootenhuis, Sara Sabina Hadida Ruah, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Sara E. Swift, Jinglan Zhou

Life of this patent

Estimating the term…

Abstract

Crystalline forms of Compound I: pharmaceutically acceptable salts thereof, and solvates and hydrates thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Claims22

Dependent claims

A substantially crystalline Compound I calcium salt hydrate Form A

Dependencies are inferred from the claim text.