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US 2025/0049956 A1Published application
In vivo reprogramming of photoreceptor cells
AssigneeCentre for Eye Research Australia
InventorChing Bong WONG
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AssigneeCentre for Eye Research Australia
InventorChing Bong WONG
Estimating the term…
The invention relates to in vivo methods and compositions for converting one cell type to another cell type. In particular, the invention relates to transdifferentiation of a cell to a photoreceptor cell, preferably a rod photoreceptor cell. In one aspect, the invention provides an in vivo method for reprogramming a source cell, the method comprising increasing the protein expression of one or more transcription factors, or biologically active fragments or variants thereof, in the source cell, wherein the source cell is reprogrammed to exhibit at least one characteristic of a target cell, wherein the source cell is a glial cell, the target cell is a photoreceptor cell; and the transcription factors are one or more of those selected from ASCLI, NEURODI, NRL, NR2E3, RAX, RORB, OTX2, CRX and PAX6.
An in vivo method for reprogramming a source cell, the method comprising increasing the protein expression of one or more transcription factors, or biologically active fragments or variants thereof, in the source cell, wherein the source cell is reprogrammed to exhibit at least one characteristic of a target cell, wherein:
A nucleic acid comprising an expression construct encoding one or more transcription factors selected from ASCL1, NEUROD1, NRL, NR2E3, RAX, RORB, OTX2, CRX and PAX6 or biologically active fragments or variants thereof.
Dependencies are inferred from the claim text.