ANTI-CD39 Antibody-Drug Conjugate And Use Thereof

An antibody-drug conjugate represented by general formula (I) or a pharmaceutically acceptable salt or solvate thereof:

• wherein
• L is a linker;
• D is a cytotoxin molecule;
• “” is a bond;
• n is an average conjugation quantity of the cytotoxin molecule conjugated to the antibody, 0<n≤10, preferably 0.8≤n≤5.5, and n can be an integer or a non-integer;
• Ab is an anti-CD39 antibody or an antigen-binding fragment thereof, preferably comprising the following CDRs:
• an HCDR1, the amino acid sequence of which is set forth in SEQ ID NO:
• 1, or which comprises the amino acid sequence set forth in SEQ ID NO:
• 1;
• an HCDR2, the amino acid sequence of which is set forth in SEQ ID NO:
• 2, or which comprises the amino acid sequence set forth in SEQ ID NO:
• 2;
• an HCDR3, the amino acid sequence of which is set forth in SEQ ID NO:
• 3, or which comprises the amino acid sequence set forth in SEQ ID NO:
• 3;
• an LCDR1, the amino acid sequence of which is set forth in SEQ ID NO:
• 4, or which comprises the amino acid sequence set forth in SEQ ID NO:
• 4;
• an LCDR2, the amino acid sequence of which is set forth in SEQ ID NO:
• 5, or which comprises the amino acid sequence set forth in SEQ ID NO:
• 5;
• and
• an LCDR3, the amino acid sequence of which is set forth in SEQ ID NO:
• 6, or which comprises the amino acid sequence set forth in SEQ ID NO:
• 6.