Antibody-drug conjugate and use thereof
AssigneeShanghai Institute of Biological Products Co., Ltd.
InventorsAidong QU, Hongyuan LIANG, Wenyan SHEN, Jingye ZHU, Jianhua QIU, Xu ZHOU
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Abstract
A linker, comprising an amino acid unit (RL). The RL comprises -Val-Ala-Q-Gly-Phe-Gly-, wherein Q is a bond, a single amino acid or a dipeptide. By optimizing a polypeptide sequence, the purpose of more effectively releasing small molecule drugs in tumor cells by ADC drugs is achieved. In addition, the present invention further relates to linker drug containing the above-mentioned linker, a conjugate, and the use of the linker drug and the conjugate.
Claims21
1-57. (canceled)
A linker, comprising an amino acid unit (RL), wherein RL comprises -Val-Ala-Q-Gly-Phe-Gly-, wherein Q is a bond, a single amino acid, or a dipeptide.
Dependencies are inferred from the claim text.