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US 2025/0049925 A1Published application
Use of vitamin e tpgs as a taste masking agent for bitter drugs
AssigneeHyloris Developments SA
InventorAtul Patil
Life of this patent
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Abstract
The invention involves novel, oral solutions of bitter drugs using Vitamin E TPGS as a masking agent and methods of using the same (e.g., for treating attention deficit/hyperactivity disorder (ADHD)). Atomoxetine (e.g., Atomoxetine HCl) is an example of a bitter drug whose bitterness can be masked by the presence of Vitamin E TPGS alone or in combination with additional ingredients.
Claims20
An atomoxetine solution, comprising:
- a) about 4-8 mg/mL atomoxetine;
- b) about 12.5-25 mg/mL Vitamin E TPGS;
- c) about 25-120 mg/mL of propylene glycol;
- d) a preservative comprising:
- i) about 1.5-2 mg/mL of methyl paraben;
- and,
- ii) about 0.1-0.4 mg/mL of propyl paraben;
- and,
- e) about 4-6 mg/mL of sucralose;
- f) a flavoring agent, comprising an agent selected from:
- i) a first flavoring agent, comprising:
- about 1-3 mg/mL of cherry flavor;
- and,
- ii) a second flavoring agent, comprising:
- a) about 0.5-1.5 mg/mL of orange flavor;
- and,
- b) about 0.5-1.5 mg/mL of peppermint flavor;
- and
- g) water;
- wherein the solution is formed from atomoxetine or a pharmaceutically acceptable salt thereof.
17 more elements
Dependencies are inferred from the claim text.