Back to results
US 2025/0049920 A1Published application
Membrane surface protein containing gpi anchor region
AssigneeShanghai Juncell Therapeutics Co., Ltd.
InventorsHuajun JIN, Ying ZHOU, Chao WANG, Chen HUANG
Life of this patent
Estimating the term…
Abstract
Provided is a membrane surface protein containing a GPI anchor region. Specifically, provided are a fusion protein comprising a functional domain and a GPI anchor region, and the use thereof. The fusion protein can effectively activate and proliferate immune cells, and improve the effector function of immune cells.
Claims21
A fusion protein comprising a functional domain and a GPI anchor region, wherein;
- the functional domain functions through dimerization or multimerization, and the GPI anchor region comprises one or more molecules selected from the groups consisting of:
- CD44, CD56, CD73, CD55, Thy1, AchE, IAP, ALPP, CD59, CD14, CD16, CD24, CD28, CD48, CD52, CD58, CD66a, CD66c, CD66d, CD66e, CD67, CD87, CD108, CD157, uPAR, JMH protein, GDNFR, CNTFR, TAG-1, PrP, phosphatidylinositol protein, semaphorin 7, CEA, GFR, Ly6G, transferrin receptor, contactin (F3) and T-cadherin, or GPI anchor domains thereof.
(canceled)
Dependencies are inferred from the claim text.