Treatment of nudt2 mutation
OwnerRamesh PILLAI, Hao WU +1inventors
InventorsRamesh PILLAI, Hao WU, David HOMOLKA
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Abstract
The disclosure relates to a method of treating Nudt2 disorder in a subject, and a composition for use in said method. The disclosure also relates to an animal model of Nudt2 disorder, and a method of diagnosing a Nudix disorder.
Claims21
A method of preventing or treating Nudt2 disorder in an individual, the method comprising administering to the individual an agent whose administration reduces type I interferon (IFN) signalling in the individual.
(canceled)
An animal model of Nudt2 disorder, wherein the animal lacks expression of functional NUDT2 protein.
A method of diagnosing a Nudix disorder in an individual, comprising identifying an increased amount of substrate for a Nudix enzyme in a sample obtained from the individual, relative to a reference value.
Dependencies are inferred from the claim text.