Blocking and reversing extracellular vesicle driven transcriptomic transformation with annexin v treatment

Abstract

Transcriptomic changes induced by uptake of extracellular vesicles (EVs) are blocked or reversed by administration of an effective dose of Annexin V protein (AnxV), e.g. by administration of AnxV to a tumor microenvironment (TME). In some embodiments, administration of AnxV is combined with a second anti-cancer therapy. In some embodiments, cells present in the TME are evaluated for transcriptional changes associated with EV uptake following administration of the effective dose of AnxV.

Dependencies are inferred from the claim text.