Surfactant Lipids, Compositions Thereof, and Uses Thereof
AssigneeNational Jewish Health
InventorsDennis R. Voelker, Mari Numata-Nakamura
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Abstract
The invention generally relates to methods to inhibit inflammation or pathogen infection by administering at least one anionic lipid or compositions comprising at least one anionic lipid to an individual. The invention also relates to methods to prevent or inhibit respiratory syncytial virus (RSV) infection by administering at least one anionic lipid or compositions comprising at least one anionic lipid to an individual. The invention further relates to compositions comprising randomly mixed surfactant lipids and methods to produce the compositions.
Claims73
A method to inhibit inflammation or pathogen infection, comprising administering to an individual who has, or is at risk of developing said inflammation or pathogen infection, an amount of at least one anionic lipid or related compound, wherein the amount of the anionic lipid or related compound is effective to inhibit said inflammation or pathogen infection, and wherein the anionic lipid has the following characteristics:
- a) has a hydrophobic portion;
- b) has a negatively charged portion;
- and
- c) has an uncharged, polar portion.
A method to prevent or inhibit viral infection, comprising administering to an individual who has, or is at risk of developing a viral infection, at least one anionic lipid or related compound, wherein the amount of the anionic lipid or related compound is effective to prevent or inhibit said viral infection, and wherein the anionic lipid has the following characteristics:
- a) has a hydrophobic portion;
- b) has a negatively charged portion;
- and
- c) has an uncharged, polar portion.
A method to prevent or inhibit respiratory syncytial virus (RSV) infection, comprising administering to an individual who has, or is at risk of developing a viral infection, at least one anionic lipid or related compound, wherein the amount of the anionic lipid or related compound is effective to prevent or inhibit said RSV infection, and wherein the anionic lipid has the following characteristics:
- a) has a hydrophobic portion;
- b) has a negatively charged portion;
- and
- c) has an uncharged, polar portion.
A method to inhibit inflammation, comprising administering to an individual who has, or is at risk of developing said inflammation, a composition comprising at least one anionic lipid or related compound, wherein the anionic lipid or related compound is effective to inhibit said inflammation, and wherein the anionic lipid has the following characteristics:
- a) has a hydrophobic portion;
- b) has a negatively charged portion;
- and
- c) has an uncharged, polar portion;
- and
- wherein the composition is selected from the group consisting of:
- i) a homogeneous lipid preparation consisting of the anionic lipid or related compound;
- ii) a composition comprising a homogeneous lipid preparation of the anionic lipid or related compound and at least one agent for the treatment of inflammation;
- iii) a composition comprising a preparation of randomly mixed surfactant lipids combined with a homogeneous lipid preparation of the anionic lipid or related compound;
- and
- iv) a preparation of randomly mixed surfactant lipids, wherein the anionic lipid or related compound comprises at least about 50% of the total lipids in said randomly mixed surfactant lipids.
A method to produce a surfactant composition, comprising:
- a) providing a substantially homogeneous lipid preparation of at least one anionic lipid or related compound, wherein the anionic lipid has the following characteristics:
- i) has a hydrophobic portion;
- ii) has a negatively charged portion;
- and
- iii) has an uncharged, polar portion;
- and
- b) adding the preparation of (a) to a preparation of randomly mixed surfactant lipids.
A surfactant composition comprising a mixture of:
- a) a preparation of randomly mixed surfactant lipids;
- and
- b) one or more substantially homogeneous lipid preparations of at least one anionic lipid or related compound, wherein the anionic lipid has the following characteristics:
- i) has a hydrophobic portion;
- ii) has a negatively charged portion;
- and
- iii) has an uncharged, polar portion;
- wherein the preparation of (b) is added to the preparation of (a) to form a composition in which there is no significant fusion or intermixing of lipids between lipid bilayers of (a) and (b).
A lipid composition comprising randomly mixed surfactant lipids, wherein at least 50% of the total lipids in the composition is comprised of one or more anionic lipids or related compounds, wherein the anionic lipid has the following characteristics:
- a) has a hydrophobic portion;
- b) has a negatively charged portion;
- and
- c) has an uncharged, polar portion.
Dependencies are inferred from the claim text.