Back to results
US 2025/0049820 A1Published application
Tetracycline compositions
AssigneeMelinta Subsidiary Corp.
InventorsDavid C. GRIFFITH, Serge Henri BOYER, Scott J. HECKER, Michael N. DUDLEY
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.
Claims30
A water-soluble solid composition comprising minocycline or a salt thereof and a magnesium cation;
- wherein:
- the molar ratio of the magnesium cation to the minocycline is greater than 4:1 and less than or equal to about 10;
- and
- the solid composition is in the form of a lyophilizate, wherein upon reconstitution of the solid composition, a solution having a pH greater than 4 and less than 7 and suitable for intravenous administration is formed.
1 more element
A water-soluble solid composition comprising minocycline or a salt thereof and magnesium sulfate;
- wherein:
- the solid composition comprises at least about 100 mg of minocycline or salt thereof;
- the molar ratio of the magnesium to the minocycline is about 5:1;
- and
- the solid composition is in the form of a lyophilizate, wherein upon reconstitution of the solid composition, a solution having a pH greater than 4.5 and less than 6 and suitable for intravenous administration is formed.
2 more elements
Dependencies are inferred from the claim text.