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US 2025/0049793 A1Published application
Pyrazole pyrimidine derivative and uses thereof
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsYinon Ben-Neriah, Guy Brachya, Ido Burstain, Waleed Minzel, Int Snir-Alkalay, Joseph P. Vacca, Dansu Li
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Abstract
The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAK1) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
Claims4
-53. (canceled)
A compound having the formula:
- or a pharmaceutically acceptable salt thereof.
A compound having the formula:
- or a pharmaceutically acceptable salt thereof.
A compound having the formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.