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US 2025/0049791 A1Published application
Synthesis of MEK7 Inhibitors and methods of Use Thereof
OwnerKarl A. Scheidt, Dalton Robert Kim +1inventors
InventorsKarl A. Scheidt, Dalton Robert Kim, Meghan Jo Orr
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Abstract
Disclosed herein are 4-phenoxypyrimidine compounds and derivatives thereof for use as inhibitors of mitogen-activated protein kinase 7 (MEK7). The disclosed compounds and pharmaceutical compositions thereof may be used in methods for treating a disease or disorder associated with MEK7 activity, including cell proliferative diseases and disorders associated with MEK7 activity, such as cancer.
Claims20
A compound having a formula I, or a salt or hydrate thereof:
- wherein
- R1 is hydrogen or alkyl;
- R2 is selected from the group consisting of alkyl, cycloalkyl, heterocycloalkyl, -alkylene-heteroaryl, -alkylene-aryl, wherein aryl is optionally substituted with one or more substituents selected from the group consisting of halo, alkyl, haloalkyl, and alkoxy;
- or —NR1R2 together form a heterocycloalkyl;
- R3 is hydrogen or alkyl;
- R4 is —C(O)R5;
- and
- R5 is alkenyl or alkyl optionally substituted with one or more substituents selected from halo and alkoxy.
5 more elements
Dependencies are inferred from the claim text.