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US 2025/0049770 A1Published application
Phosphodiesterase 4 Inhibitor Decreases Thrombosis in Simulated ECMO Model
AssigneesBoard of Regents, The University of Texas System, The Government of the United States, as represented by the Secretary of the Army
InventorsAndrew Duncan Joseph MEYER, Andrew P. CAP, Ricardo AGUIAR
Life of this patent
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Abstract
A method of treating thrombosis in a subject comprising administering an effective amount of a PDE4 inhibitor.
Claims20
A method of treating thrombosis in a subject comprising administering an effective amount of a PDE4 inhibitor.
A method of providing a mechanical circulation system to a subject comprising:
- a pump circuit operable to pump a volume of blood of the subject outside the body of the subject,
- introducing an inhibitor to the volume of blood that inhibits the pro-thrombotic function of leukocytes in the volume of blood, and
- the pump circuit pumping the volume of blood with the inhibitor.
A mechanical circulation system comprising:
- a pump circuit operable to pump a volume of blood of a subject outside a body of a subject,
- wherein introduction of an inhibitor to the volume of blood inhibits pro-thrombotic function of leukocytes in the volume of blood and reduces formation of thrombotic deposits on one or more surfaces of the pump circuit of the mechanical circulation system.
Dependencies are inferred from the claim text.