Loading patent…
AssigneesAsymchem Laboratories (Tianjin) Co., Ltd., Jilin Asymchem Pharmaceuticals Co., Ltd.
InventorsGage JAMES, McLaws MARK, Wenchun ZHANG, Chaoyong CHEN, Dingding JING, Baojie ZHANG, Yong JIANG
Estimating the term…
The disclosure provides a new crystal form of ertapenem sodium and preparation method therefor. The new crystal form of ertapenem sodium has 27 principal characteristic peaks in an X-ray powder diffraction diagram. The crystal form of ertapenem sodium of the disclosure has a rod-like crystal habit, which has a large particle size, is not prone to aggregation and is easier to dry, and a product with high crystallinity and high purity may be obtained by simple drying treatment. Meanwhile, the crystal form of the disclosure has better stability, and the crystal form may remain unchanged to a maximum extent in subsequent washing and drying processes, thereby further improving the purity of the product.
A new crystal form of ertapenem sodium, having a structure shown in Formula I, wherein the new crystal form of ertapenem sodium has characteristic peaks at a diffraction angle (2θ) value of 4.3±0.2°, 5.1±0.2°, 7.1±0.2°, 8.2±0.2°, 10.8±0.2°, 12.0±0.2°, 12.7±0.2°, 13.9+0.2°, 14.7±0.2°, 15.5±0.2°, 16.3±0.2°, 17.5±0.2°, 18.4±0.2°, 18.8±0.2°, 19.1±0.2°, 20.0±0.2°, 21.3±0.2°, 22.1±0.2°, 24.5±0.2°, 24.9±0.2°, 26.5±0.2°, 28.0±0.2°, 29.3±0.2°, 31.7±0.2°, 32.6±0.2°, 34.7±0.2° and 36.2±0.2° in an X-ray powder diffraction diagram using a Cukα ray:
Dependencies are inferred from the claim text.