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OwnerZhicheng XIAO, David Xiang YU +2inventors
InventorsZhicheng XIAO, David Xiang YU, Colin William POUTON, Zhiyong HE
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The disclosure relates to nitroimidazoles and related compounds and derivatives, formulations thereof, and their use in the prevention and/or treatment of infectious disease in animals. In particular, the disclosure relates to 5-nitroimidazoles and related compounds and derivatives, formulations thereof, and their use in the prevention and/or treatment of infectious disease in animals including bacterial, viral, parasitic or fungal infections. More particularly, the invention relates to metronidazole and related compounds and derivatives, formulations thereof, and their use in the prevention and/or treatment of infectious disease caused by Clostridium species. Most preferably, the nitroimidazole is metronidazole administered in combination with berberine, or a berberine alkaloid, in a synergistic weight ratio of 1:1 or 1:2.
An animal feed supplement comprising a 5-nitroimidazole and a berberine alkaloid in a weight ratio of between about 1:10 and about 10:1.
A method of reducing the risk of a Clostridium infection in a food producing animal comprising:
Dependencies are inferred from the claim text.