20-hete receptor (gpr75) antagonists and methods of use

A compound of the formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• R2 and R3 are each, independently, OH, C1-C3, F, or H, provided that at least one of R2 and R3 is OH;
• R4 is C1-C3, H, F, or —CH2N3 (azide);
• X is C;
• m is 1;
• n is 2;
• p is 1;
• q is 1;
• and
• R1 is NR8R9 or C(O)R6, wherein:
• R6 is OR7, NR8R9, a D-/L-/D,L-α-amino acid (MW<250) other than glycine, —NHS(O)2R10, glycerol, glyceride mono- or diester (MW<800), or a carboxylate isostere or mimetic selected from the group consisting of:
• —P(O)(OH)2, —S(O)2OH,
• wherein ii) lower alkyl is a C1-C6 alkyl or cycloalkyl;
• R7 is C1-C6 alkyl or cycloalkyl, or benzyl;
• R8 and R9 are each, independently, H, C1-C6 alkyl or cycloalkyl, or benzyl, or R8 and R9 together constitute a 3-7 membered ring with the nitrogen;
• and
• R10 is phenyl, C1-C5 alkyl or cycloalkyl, or CF3.