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AssigneeBoston Scientific Scimed, Inc.
InventorsJoseph Thomas Delaney, JR., Cristian Parisi, Yen-Hao Hsu, Rick Dorn
Estimating the term…
In some aspects, the present disclosure provides reactive polymers that comprise one or more hydrophilic polymer segments having a plurality of hydrophilic polymer segment ends and a plurality of reactive moieties covalently linked to at least a portion of the hydrophilic polymer segment ends. The reactive moieties are 3,4-substituted-2,5-pyrrolidinedione moieties in which the 3-carbon and the 4-carbon form part of at least one ring in addition to the 2,5-pyrrolidinedione ring, and the 2,5-pyrrolidinedione ring nitrogen atom of each of the 3,4-substituted-2,5-pyrrolidinedione moieties is linked to one of the hydrophilic polymer segment ends. In other aspects, the present disclosure provides systems for forming hydrogel compositions and methods of treatment that employ such reactive polymers and methods of synthesizing such reactive polymers.
A reactive polymer comprising one or more hydrophilic polymer segments having a plurality of hydrophilic polymer segment ends and a plurality of reactive moieties covalently linked to at least a portion of the hydrophilic polymer segment ends, wherein the reactive moieties are 3,4-substituted-2,5-pyrrolidinedione moieties in which the 3-carbon and the 4-carbon form part of at least one ring in addition to the 2,5-pyrrolidinedione ring and wherein the 2,5-pyrrolidinedione ring nitrogen atom of each of the 3,4-substituted-2,5-pyrrolidinedione moieties is linked to one of the hydrophilic polymer segment ends.
A system for forming a hydrogel composition that comprises (a) a nucleophilic compound and (b) a reactive polymer comprising one or more hydrophilic polymer segments having a plurality of hydrophilic polymer segment ends and a plurality of reactive moieties covalently linked to at least a portion of the hydrophilic polymer segment ends, wherein the reactive moieties are 3,4-substituted-2,5-pyrrolidinedione moieties in which the 3-carbon and the 4-carbon form part of at least one ring in addition to the 2,5-pyrrolidinedione ring and wherein the 2,5-pyrrolidinedione ring nitrogen atom of each of the 3,4-substituted-2,5-pyrrolidinedione moieties is linked to one of the hydrophilic polymer segment ends.
A synthesis method comprising condensing (a) a 3,4-substituted-1-hydroxy-2,5-pyrrolidinedione compound in which the 3-carbon and the 4-carbon form part of at least one ring in addition to the 2,5-pyrrolidinedione ring with (b) a precursor polymer comprising one or more hydrophilic polymer segments having a plurality of hydrophilic polymer segment ends that are terminated in carboxylic acid groups, thereby forming a reactive polymer comprising a plurality of reactive moieties covalently linked to the hydrophilic polymer segment ends, wherein each of the reactive moieties is a 3,4-substituted-2,5-pyrrolidinedione moiety in which the 3-carbon and the 4-carbon form part of at least one ring in addition to the 2,5-pyrrolidinedione ring, and wherein the 2,5-pyrrolidinedione ring nitrogen atom of the 3,4-substituted-2,5-pyrrolidinedione moiety is linked to one of the hydrophilic polymer segment ends.
Dependencies are inferred from the claim text.