Mirror-image selection of l-nucleic acid aptamers

Abstract

A method for screening L-nucleic acid aptamers for binding to a target molecule is disclosed. The method comprises: (a) contacting the plurality of L-nucleic acid aptamers with the target molecule under conditions that selectively capture target-bound L-nucleic acid aptamers from the plurality of L-nucleic acid aptamers; (b) amplifying L-nucleic acid aptamers of the target-bound L-nucleic acid aptamers to generate amplified, double-stranded L-nucleic acid oligonucleotides; and (c) isolating amplified double stranded L-nucleic acid oligonucleotides using an electrophoresis based method, thereby screening the plurality of L-nucleic acid aptamers.

Dependencies are inferred from the claim text.