COMPOSITIONS AND METHODS FOR TREATMENT OF CANCERS USING MODIFIED siRNA-GEM AGENTS

A method of treating a subject having cancer, comprising:

• administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a modified siRNA molecule comprising gemcitabine;
• wherein the composition further comprises a histidine-lysine copolymer carrier;
• and
• wherein the siRNA molecule further comprises at least one sequence selected from the group consisting of SEQ ID Nos. 1-2, SEQ ID Nos. 3-4, SEQ ID Nos. 5-6, SEQ ID Nos. 7-8, SEQ ID Nos. 9-10, SEQ ID No. 13, and SEQ ID No. 14,
• wherein the subject is treated by said administration of the pharmaceutical composition, resulting in attenuated or inhibited growth of said cancer.