MIC Antibodies and Binding Agents and Methods of Using the Same

A method of treating a cancer, comprising administering to a subject in need thereof:

• a therapeutically effective amount of an isolated monoclonal antibody or antigen-binding portion thereof that specifically binds MIC, wherein the antibody or antigen-binding portion thereof each comprises a heavy chain variable (VH) region and a light chain variable (VL) region, wherein the VH region comprises a complementarity determining region HCDR1 sequence having the amino acid sequence set forth in SEQ ID NO:11, a HCDR2 having the amino acid sequence set forth in SEQ ID NO:12, and a HCDR3 having the amino acid sequence set forth in SEQ ID NO:13, and wherein the VL region comprises a LCDR1 sequence having the amino acid sequence set forth in SEQ ID NO:14, a LCDR2 having the amino acid sequence set forth in SEQ ID NO:15, and a LCDR3 having the amino acid sequence set forth in SEQ ID NO:16, wherein the VH region comprises an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:
• 1, and the VL region comprises an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:
• 2;
• and
• an adoptive cell therapy.