Methods of preventing, treating, or reducing the severity of coronavirus disease 2019 (covid-19)
AssigneeCity of Hope
InventorsDon J. DIAMOND, Flavia CHIUPPESI
Life of this patent
Estimating the term…
Abstract
Disclosed are methods of preventing or treating COVID-19 caused by a coronavirus infection or variants thereof by administration to a subject in need thereof a synthetic MVA-based vaccine. Also disclosed are methods of preventing or treating a coronavirus infection, or increasing an immune response in a subject who has previously received a SARS-CoV-2 vaccine by administration to the subject or a booster dose of a synthetic MVA-based vaccine.
Claims25
A method of vaccinating or protecting a subject against coronavirus disease 2019 (COVID-19) or preventing or reducing the severity of COVID-19 caused by a coronavirus infection or boosting an immune response to coronavirus infection in a subject, comprising administering a composition comprising a synthetic modified vaccinia Ankara (sMVA) vector or virus capable of expressing one or more DNA sequences encoding a spike (S) protein and a nucleocapsid (N) protein or variants or mutants thereof, wherein the method (i) prevents the coronavirus infection or (ii) prevents or reduces the severity of COVID-19 caused by the coronavirus infection.
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A method of treating COVID-19 in a subject, comprising administering a composition comprising a synthetic modified vaccinia Ankara (sMVA) vector or virus capable of expressing one or more DNA sequences encoding a spike (S) protein and a nucleocapsid (N) protein or variants or mutants thereof.
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Dependencies are inferred from the claim text.