Activating appendages to induce polypharmacology in peptide hormone analogues, including dual glp-1r / gip agonism

A compound comprising GLP-1 or GIP in which at least one side chain of a residue in the GLP-1 and/or the GIP is modified to contain a side chain comprising:

• wherein:
• B is an integer of from 1 to 6;
• T is an integer of from 0 to 6, or the carbon atom bearing the subscript T is a substituted or unsubstituted C3-C6-cycloalkyl and T=1;
• and
• R is selected from the group consisting of polycyclic aromatic hydrocarbons and
• wherein R1 is independently selected from the group consisting of an unsubstituted polycyclic aromatic hydrocarbon, halogen, a polycyclic aromatic hydrocarbon having up to three substitutions, an unsubstituted heterocycle, a heterocycle having up to three substitutions, and
• wherein R4, R5, and R6 are independently selected from the group consisting of H, halogen, —OH, —C1-C6-linear or branched, unsubstituted or alkyl, and —O—C1-C6-linear or branched, substituted or unsubstituted alkyl;
• and
• R2 and R3 are independently selected from the group consisting of H, halogen, —OH, —C1-C6-linear or branched, substituted or unsubstituted alkyl, —C1-C6-linear or branched, substituted or unsubstituted alkylaryl, —O—C1-C6-linear or branched, substituted or unsubstituted alkyl, —O—C1-C6-linear or branched, substituted or unsubstituted alkylaryl, and the groups listed for R1;
• and salts thereof.