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US 2025/0025714 A1Published application
Non-invasive method for suppressing spreading depolarization in human brains
AssigneeCarnegie Mellon University
InventorsAlireza Chaman Zar, Pulkit Grover, Shawn K. Kelly, Maysam Chamanzar, Shilpa George, Anjali Menon
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Abstract
Methods providing reliable and non-invasive ways to suppress spreading depolarization waves leading to cortical spreading depression are disclosed. A stimulation signal is applied at the location of and surrounding the location of the spreading depolarization and the amplitude and focal point of the stimulation signal are randomly varied, causing suppression of the spreading depolarization wave.
Claims18
A method of suppressing a spreading depolarization in a brain comprising:
- determining a location of the spreading depolarization in the brain;
- providing a stimulation signal to the brain focused on a volume of the brain at and surrounding the determined location of the spreading depolarization;
- and
- randomly varying an amplitude and focal point of the stimulation signal to suppress the a spreading depolarization.
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