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US 2025/0025498 A1Published application
Methods and Compositions for Xenotransplantation
AssigneeThe Trustees of Columbia University in the City of New York
InventorsMegan Sykes, Yong-Guang Yang
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Abstract
Provided herein are methods of xenotransplantation, for example, porcine to human transplantation. Also provided herein are extracellular vesicles (“EVs”, e.g., exosomes) and compositions comprising the same. e.g. EVs expressing human CD47. Further provided herein are methods of making EVs and use thereof for xenotransplantation. In some aspects, the methods of xenotransplantation comprise steps of expressing human CD47 on xenografts.
Claims72
A method of xenotransplantation, the method comprising
- a. obtaining an organ from a donor swine;
- b. cross-dressing the organ with human CD47;
- and
- c. transplanting the organ into a human recipient.
1 more element
Dependencies are inferred from the claim text.