Derivatized chitosan polymers and methods of treating vascular disorders
AssigneeSynedgen, Inc.
InventorsShenda M. Baker, William P. Wiesmann
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Abstract
Described herein are methods for treating inflammation, swelling and secondary damage of the vascular and lymphatic system in a subject, for example of the brain, spinal cord, and lungs; from organ reperfusion, e.g., resulting from endothelial leakage, glycocalyx dysfunction or loss of structural integrity of the glycocalyx.
Claims22
A method of treating a disorder of the vascular system, the method comprising intravenously administering a polymer to a subject in need thereof, thereby treating the disorder, wherein the polymer is a compound of the following structure:
- wherein:
- n is an integer between 20 and 6000;
- and
- each R1 is independently selected for each occurrence from hydrogen, acetyl,
- wherein at least 25% of R1 substituents are H, at least 1% of R1 substituents are acetyl, and at least 2% of R1 substituents are
9-26. (canceled)
33-40. (canceled)
A method of treating a disorder in a subject in need thereof, wherein the disorder is dysfunction of the glycocalyx or loss of structural integrity of the glycocalyx, the method comprising intravenously administering a polymer to the subject, thereby treating the disorder, wherein the polymer is a compound of the following structure:
- wherein:
- n is an integer between 20 and 6000;
- and
- each R1 is independently selected for each occurrence from hydrogen, acetyl,
- wherein at least 25% of R1 substituents are H, at least 1% of R1 substituents are acetyl, and at least 2% of R1 substituents are
Dependencies are inferred from the claim text.