Mixed amide ester containing lipids for use in lipid nanoparticles

A compound having a structure of Formula (I):

• or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein:
• G1 is —NR1a—C(═O)—, —C(═O)—NR1b—, or —N(C(═O)R1d)—;
• G2 is —NR2a—C(═O)—, —C(═O)—NR2b—, or —N(C(═O)R2e)—;
• R1 is —O—C(═O)R1c or —C(═O)—OR1c;
• R2 is C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, or -L2a-R2c;
• R1a, R11, R2a, and R2b are each independently hydrogen, C1-C16 alkyl, C2-C12 alkenyl, or C2-C12 alkynyl;
• R1c is C6-C24 alkyl, C6-C24 alkenyl, or C6-C24 alkynyl;
• R2c is —O—C(═O)R2d or —C(═O)—OR2d;
• R2d is C1-C24 alkyl, C2-C24 alkenyl, or C2-C24 alkynyl;
• R1d and R2e are each independently C1-C12 alkyl;
• R3 is C1-C8 alkyl or C3-C8 cycloalkyl, each of which is optionally substituted with one or more substituents selected from the group consisting of C1-C4 alkoxy, oxo, —OH, —N(R3a)R3b, cycloalkyl, heterocyclyl, or heteroaryl;
• R3a and R3b are each independently hydrogen, C1-C4 alkyl, or C3-C8 cycloalkyl;
• L1a and L2 are each independently C2-C12 alkylene;
• L1b is C1-C12 alkylene, C2-C12 alkenylene, or C2-C12 alkynylene;
• and
• L2a is C1-C12 alkylene, C2-C12 alkenylene, or C2-C12 alkynylene,
• wherein each alkyl, alkenyl, alkynyl, alkylene, alkenylene, alkynylene, cycloalkyl, heterocyclyl and heteroaryl is optionally substituted with one or more fluoro.