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AssigneeDuquesne University of the Holy Spirit
InventorsIra Shea Buckner, Rehana Khan Leak, Aleem Gangjee, Anuj Sunil Jamenis
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The present invention is a ready-delivery oral dosage form for laboratory animals, for the testing of candidate active agents, that meets a number of design parameters. First, the oral dosage form is chewable but neither fragile nor sticky, so it does not fall apart or scatter in the living space in which it is administered—but also cannot become lodged in the animal's teeth or mouth. Second, the palatability profile is greater than the ordinary animal feed (such as rodent chow and so forth) and therefore will be consumed immediately and preferentially, when administered, prior to any other available food. Finally, the oral dosage form must be readily compounded such as with an automated tablet press without the need to add heat or volatile solvents, with inclusion of active agent added followed by optional refrigeration prior to administration.
An oral dosage form for a candidate drug for a laboratory animal, comprising a unit dosage amount of one or more candidate active agents, compounded with a particulated pre-mix material containing at least one fat source, one protein source, one carbohydrate source, one aromatic compound, and at least one binder, all of which ingredients adhere under pressure and ambient conditions, without needing added heat or volatile solvents, to make a single unit dosage form which is neither fragile nor sticky.
A pre-mix for compounding one or more candidate active agents in or near an animal testing laboratory, comprising an admixture, in particulated form comprising particles, of a fat source, a protein source, a carbohydrate source, and at least one binder, wherein at least one of said fat source, said protein source or said carbohydrate source contains an aromatic compound and wherein a preponderance of said particles are in the size range of 75-500 microns.
A method for compounding one or more candidate active agents for oral administration to one or more laboratory animals, comprising the steps of:
Dependencies are inferred from the claim text.