Guidewire apparatus and method for multiple parameter analysis of coronary stenosis

An intravascular device comprising:

• an elongate tubular body having a distal end region configured to be positioned within a vessel of a heart of a patient, and
• one or more proximal electrode pairs disposed on an exterior surface of the elongate tubular body proximate the distal end region, wherein the one or more proximal electrode pairs are configured to be positioned upstream of a narrowing within the vessel;
• one or more distal electrode pairs disposed on an exterior surface of the elongate tubular body proximate the distal end region, wherein the one or more distal electrode pairs are configured to be positioned downstream of the narrowing;
• and
• a computing system operatively coupled to the elongate tubular body and comprising at least one data processor and a memory storing instructions which, when executed by the at least one processor, cause the at least one processor to perform operations comprising:
• acquiring a first electrical signal from the one or more proximal electrode pairs and a second electrical signal from the one or more distal electrode pairs, and
• generating, within a user interface display of the computing system, a first electrogram from the first electrical signal and a second electrogram from the second electrical signal, wherein the user interface display enables a comparison of the first electrogram to the second electrogram to determine a clinical relevance of the narrowing.

A method comprising:

• positioning an elongate tubular body within a vessel of a heart of a patient, wherein the elongate tubular body comprises one or more proximal electrode pairs and one or more distal electrode pairs, wherein the one or more proximal electrode pairs are positioned upstream of a narrowing within the vessel and the one or more distal electrode pairs are positioned downstream of the narrowing;
• acquiring, via a computing system operatively coupled to the elongate tubular body, a first electrical signal from the one or more proximal electrode pairs and a second electrical signal from the one or more distal electrode pairs;
• generating, within a user interface display of the computing system, a first electrogram from the first electrical signal and a second electrogram from the second electrical signal;
• comparing the first electrogram to the second electrogram to determine a clinical relevance of the narrowing.