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US 2025/0020654 A1Published application
Screening methods for parp modulators
AssigneeRibon Therapeutics, Inc.
InventorsTimothy J.N. Wigle, Danielle J. Blackwell, Kevin Wayne Kuntz, Melissa Marie Vasbinder, Laurie B. Schenkel, Kerren Kalai Swinger
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Abstract
The present disclosure is related to methods of identifying Poly(ADP-ribose) polymerases (PARP) inhibitors, and the methods of using PARP probes.
Claims8
1-14. (canceled)
A method of identifying an inhibitor for Poly (ADP-ribose) polymerase (PARP), the method comprising:
- contacting a polypeptide comprising a PARP catalytic domain with a PARP probe in the presence of a test compound, wherein the PARP probe comprises a fluorophore;
- exposing the probe to polarized excitation light, thereby generating fluorescence;
- determining a fluorescence polarization value of the fluorescence;
- and
- identifying the test compound as an inhibitor for PARP based on the fluorescence polarization value of the fluorescence.
2 more elements
21-37. (canceled)
Dependencies are inferred from the claim text.