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US 2025/0019661 A1Published application
Sc-beta cells and compositions and methods for generating the same
AssigneePresident and Fellows of Harvard College
InventorsQuinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey Robert Millman, Michael Saris Segel, Mads Gurtler
Life of this patent
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Abstract
Disclosed herein are methods, compositions, kits, and agents useful for inducing β cell maturation, and isolated populations of SC-β cells for use in various applications, such as cell therapy.
Claims30
-23. (canceled)
A method of administering a composition to a human subject with Type 1 Diabetes, comprising the step of administering to the subject a composition comprising a plurality of cell clusters;
- wherein the plurality of cell clusters comprise a plurality of cells that express glucagon;
- wherein all of the cell clusters in the composition have a diameter <300 sm;
- and wherein at least 20% of the cells in the plurality of cell clusters are a plurality of non-native pancreatic β-cells that:
- (a) express chromogranin A, ISL1, PDX1, and C-peptide and one or more of the following genes:
- ZNT8, MNX1, or ABCC8;
- and
- (b) do not express somatostatin or glucagon.
4 more elements
Dependencies are inferred from the claim text.