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US 2025/0019453 A1Published application
Il2rb/il2g synthetic cytokines
AssigneeSynthekine, Inc.
InventorsRobert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Rene De Waal Malefyt, Sandro Vivona
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Abstract
Provided herein are IL2R binding molecules that bind to IL2Rb and IL2Rg and comprise an IL2Rg sdAb and an anti-IL2Rg VHH antibody.
Claims29
An IL2Rb/IL2Rγ binding molecule that specifically binds to IL2Rb subunit (IL2Rb) and IL2Rγ subunit (IL2Rγ),
- wherein the binding molecule causes the multimerization of IL2Rb and IL2Rγ when bound to IL2Rb and IL2Rγ, and
- wherein the binding molecule comprises a single-domain antibody (sdAb) that specifically binds to IL2Rb (an IL2Rb sdAb) and a sdAb that specifically binds to IL2Rγ (an anti-IL2Rγ sdAb).
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Dependencies are inferred from the claim text.