Antibody variable domains targeting the nkg2d receptor
AssigneeDragonfly Therapeutics, Inc.
InventorsGregory P. Chang, Ann F. Cheung, Asya Grinberg, William Haney, Bradley M. Lunde, Bianka Prinz
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Abstract
Antibody heavy chain variable domains that can be paired with antibody light chain variable domains to form an antigen-binding site targeting the NKG2D receptor on natural killer cells are described. Proteins comprising an NKG2D antigen-binding site, pharmaceutical compositions and therapeutic methods thereof, including for the treatment of cancer, are also described.
Claims80
An antibody heavy chain variable domain comprising an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:7.
An antibody heavy chain variable domain comprising an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:1.
An antibody heavy chain variable domain comprising an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:3.
An antibody heavy chain variable domain comprising an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:5.
An antibody heavy chain variable domain comprising an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:9.
A protein comprising an antigen-binding site that competes for binding to human and/or cynomolgus NKG2D with an antibody comprising a heavy chain variable region having the amino acid sequence of SEQ ID NO:7 and a light chain variable region having the amino acid sequence of SEQ ID NO:8.
A protein comprising an antigen-binding site that competes for binding to human and/or cynomolgus NKG2D with an antibody comprising a heavy chain variable region having the amino acid sequence of SEQ ID NO:85 and a light chain variable region having the amino acid sequence of SEQ ID NO:8.
A protein comprising an antigen-binding site that competes for binding to human and/or cynomolgus NKG2D with an antibody comprising a heavy chain variable region having the amino acid sequence of SEQ ID NO:
- 1 and a light chain variable region having the amino acid sequence of SEQ ID NO:2.
A protein comprising an antigen-binding site that competes for binding to human and/or cynomolgus NKG2D with an antibody comprising a heavy chain variable region having the amino acid sequence of SEQ ID NO:3 and a light chain variable region having the amino acid sequence of SEQ ID NO:4.
A protein comprising an antigen-binding site that competes for binding to human and/or cynomolgus NKG2D with an antibody comprising a heavy chain variable region having the amino acid sequence of SEQ ID NO:5 and a light chain variable region having the amino acid sequence of SEQ ID NO:6.
A protein comprising an antigen-binding site that competes for binding to human and/or cynomolgus NKG2D with an antibody comprising a heavy chain variable region having the amino acid sequence of SEQ ID NO:9 and a light chain variable region having the amino acid sequence of SEQ ID NO:20.
Dependencies are inferred from the claim text.