Resistin-specific antibody and use thereof

Abstract

The present invention relates to an antibody against resistin and use thereof and, more specifically, to a resistin antibody or antigen-binding fragment thereof that inhibits the activity of resistin by blocking resistin/CAP1 binding, a nucleic acid encoding same, a vector comprising the nucleic acid, a cell transformed with the vector, a method for preparing the antibody or antigen-binding fragment thereof, an antibody-drug conjugate comprising the antibody or antigen-binding fragment thereof, a bi- or multi-specific antibody, a chimeric antigen receptor, an immune cell containing same, and a composition for the prevention or treatment of diseases that can be treated through the inhibition of resistin activity, the composition comprising same. A novel antibody or antigen-binding fragment thereof that binds to resistin, according to the present invention, blocks resistin/CAP1 binding by binding to resistin, thereby inhibiting the activity of resistin, and thus is useful for the development of therapeutic agents for various diseases associated with resistin.

Dependencies are inferred from the claim text.