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US 2025/0019423 A1Published application
Anti-influenza b virus neuraminidase antibodies and uses thereof
AssigneeIcahn School of Medicine at Mount Sinai
InventorsPeter PALESE, Florian KRAMMER, Teddy John WOHLBOLD, Adolfo GARCIA-SASTRE
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Abstract
Provided herein are antibodies that bind to neuraminidase (NA) of different strains of influenza B virus, host cells for producing such antibodies, and kits comprising such antibodies. Also provided herein are compositions comprising antibodies that bind to NA of different strains of influenza B virus and methods of using such antibodies to diagnose, prevent or treat influenza virus disease.
Claims22
-76. (canceled)
A method for detecting an influenza B virus, comprising:
- (a) contacting cells or a biological sample with an antibody that binds to influenza B virus neuraminidase (NA), wherein the antibody comprises:
- (i) a variable heavy chain region complementarity determining region (CDR)1 comprising the amino acid sequence of SEQ ID NO:
- 67, (ii) a variable heavy chain region CDR2 comprising the amino acid sequence of SEQ ID NO:
- 68, (iii) a variable heavy chain region CDR3 comprising the amino acid sequence of SEQ ID NO:
- 69, (iv) a variable light chain region complementarity determining region (CDR)1 comprising the amino acid sequence of SEQ ID NO:
- 70, (v) a variable light chain region CDR2 comprising the amino acid sequence of SEQ ID NO:
- 71, and (vi) a variable light chain region CDR3 comprising the amino acid sequence of SEQ ID NO:
- 72;
- and
- (b) detecting the binding of the antibody to NA of an influenza B virus, wherein influenza B virus is detected if the level of binding of the antibody to NA of an influenza B virus is greater than the level of binding of the antibody to non-influenza virus infected cells or a biological sample not infected with an influenza virus.
7 more elements
-104. (canceled)
A method for detecting an influenza B virus, comprising:
- (a) contacting cells or a biological sample with an antibody that binds to influenza B virus neuraminidase (NA), wherein the antibody comprises a variable heavy chain region that is at least 95% identical to the amino acid sequences of SEQ ID NO:
- 65 and a variable light chain region that is at least 95% identical to the amino acid sequence of SEQ ID NO:
- 66;
- and
- (b) detecting the binding of the antibody to NA of an influenza B virus, wherein influenza B virus is detected if the level of binding of the antibody to NA of an influenza B virus is greater than the level of binding of the antibody to non-influenza virus infected cells or a biological sample not infected with an influenza virus.
2 more elements
Dependencies are inferred from the claim text.