Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment

A compound having the structure of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• RA is RE, hydrogen, optionally substituted acyl, optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, —ORD1, −N(RD1a)2, or —SRD1, wherein RD1 is independently selected from hydrogen, optionally substituted acyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, a nitrogen protecting group when attached to an nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom;
• RB is RE, hydrogen, optionally substituted acyl, optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or a nitrogen protecting group;
• each instance of RC and RD is, independently, RE, hydrogen, halogen, nitro, optionally substituted acyl, optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, —ORD1a, —N(RD1a)2, or —SRD1a, wherein RD1a is independently selected from hydrogen, optionally substituted acyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, a nitrogen protecting group when attached to an nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom;
• X is O, NRF, or CHRF;
• p is 1, 2, 3, or 4;
• n is 1, 2, 3, 4, or 5;
• RE is a moiety that restricts the compound of Formula (I) to the peripheral nervous system, provided that the compound of Formula (I) comprises at least one RE;
• and
• RF is a nitrogen radical that combines with RB to form a fused 5-membered heterocyclyl or heteroaryl ring,
• wherein when RB is substituted heteroaliphatic, RC is hydrogen or halogen, RD is halogen, p is 1, and n is 1, RA is not hydrogen.