Novel quinizarin derivative and preparation method thereof
AssigneeBenoBio Co., Ltd
InventorIn-Hyun LEE
Life of this patent
Estimating the term…
Abstract
Proposed is a novel quinizarin derivative, and the novel quinizarin derivative has the abilities to inhibit a BET protein, and thus can be used as a pharmaceutical composition for the prevention or treatment of BET protein-related diseases, such as cancer, autoimmune or inflammatory diseases, metabolic diseases, and viral diseases. Particularly, the novel quinizarin derivative has the abilities to inhibit lipogenesis and the expression of liposynthetic factors, and thus can be used as a pharmaceutical composition for the treatment of non-alcoholic fatty liver.
Claims10
A novel quinizarin derivative, comprising a compound represented by the following Chemical Formula 1 or 2:
- (in Chemical Formulas 1 and 2,
- R1, R2, R3, R4, R5, R6, R7 and R5 are each independently hydrogen, hydroxy, linear or branched C1-C12 alkyl which may be substituted, C3-C12 cycloalkyl which may be substituted, C6-C18 aryl which may be substituted, or alkoxy, and
- the substitution is performed by oxygen, nitrogen, sulfur, hydroxyl, linear or branched C1-C6 alkyl, C6-C20 aryl, halogen, alkoxy, ether or a combination thereof).
Dependencies are inferred from the claim text.