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US 2025/0018412 A1Published application
Volumetric measurement of micro droplets
AssigneeDH Technologies Development Pte. Ltd.
InventorsThomas R. Covey, Chang Liu
Life of this patent
Estimating the term…
Abstract
Improvements in acoustically dispensed samples that are injected into an open port probe (OPP) are described. Apparatus and method are described that calibrate the volume dispensing determination and mechanisms in the acoustic dispenser to produce accurate and precise volumetric delivery.
Claims11
A method of calibrating a droplet dispenser dispensing sample droplets from a liquid sample, comprising:
- providing a liquid sample including a calibrant of known calibrant concentration;
- dispensing a droplet of assumed droplet size from the liquid sample;
- ionizing the droplet of assumed droplet size;
- measuring a calibrant mass of calibrant in the ionized droplet using a mass spectrometer;
- and,
- determining an actual droplet size by comparing an expected calibrant mass based on the assumed droplet size with the measured calibrant mass.
3 more elements
A system for measuring a volume of fluid dispensed by a fluid dispenser, the system comprising:
- a capture probe for receiving and capturing a dispensed volume of fluid from the fluid dispenser, the dispensed volume of fluid including a calibration standard;
- an ionization source for ionizing the captured volume of fluid;
- and,
- a mass spectrometer for measuring a mass of the calibrant contained in the ionized volume of fluid.
1 more element
Dependencies are inferred from the claim text.