Anti-nectin-4-antibodies and uses thereof

A monoclonal antibody or antigen-binding fragment thereof which binds to Nectin-4 comprising:

• (a) a variable heavy chain (VH) region comprising complementarity-determining regions (CDRs) CDR-H1, CDR-H2 and CDR-H3, wherein
• (i) the CDR-H1 comprises an amino acid sequence according to SEQ ID NO:
• 1,
• (ii) the CDR-H2 comprises an amino acid sequence according to SEQ ID NO:
• 2,
• (iii) the CDR-H3 comprises an amino acid sequence according to SEQ ID NO:
• 3,
• and
• (b) a variable light chain (VL) region, particularly a VL region comprising complementarity-determining regions (CDRs) CDR-L1, CDR-L2 and CDR-L3, wherein
• (i) the CDR-L1 comprises an amino acid sequence according to SEQ ID NO:
• 4,
• (ii) the CDR-L2 comprises an amino acid sequence according to SEQ ID NO:
• 5,
• (iii) the CDR-L3 comprises an amino acid sequence according to SEQ ID NO:
• 6,
• or
• (c) a variable heavy chain (VH) region comprising complementarity-determining regions (CDRs) CDR-H1, CDR-H2 and CDR-H3, wherein
• (i) the CDR-H1 comprises an amino acid sequence according to SEQ ID NO:
• 7,
• (ii) the CDR-H2 comprises an amino acid sequence according to SEQ ID NO:
• 8,
• (iii) the CDR-H3 comprises an amino acid sequence according to SEQ ID NO:
• 9, and
• (d) a variable light chain (VL) region, particularly a VL region comprising complementarity-determining regions (CDRs) CDR-L1, CDR-L2 and CDR-L3, wherein
• (i) the CDR-L1 comprises an amino acid sequence according to SEQ ID NO:
• 10,
• (ii) the CDR-L2 comprises an amino acid sequence according to SEQ ID NO:
• 11,
• (iii) the CDR-L3 comprises an amino acid sequence according to SEQ ID NO:
• 12.