Antibody specific to ephrin type-a receptor 10, fusion protein containing the same, chimeric antigen receptor t-cell expressing the same and uses thereof

A polypeptide comprising an antibody or antigen-binding fragment thereof that is specific to an epitope in ephrin type-A receptor 10 A10 (EphA10);

• wherein the antibody or antigen-binding fragment thereof comprises complementarity determining regions (CDRs) of a heavy chain variable region and complementarity determining regions of a light chain variable region, wherein the complementarity determining regions of the heavy chain variable region comprise CDRH1, CDRH2 and CDRH3 regions, and the complementarity determining regions of the light chain variable region comprise CDRL1, CDRL2 and CDRL3 regions, and wherein:
• the CDRH1 region comprises the amino acid sequence of SEQ ID NO:
• 1 or a substantially similar sequence thereof;
• the CDRH2 region comprises the amino acid sequence of SEQ ID NO:
• 2 or a substantially similar sequence thereof;
• the CDRH3 region comprises the amino acid sequence of SEQ ID NO:
• 3 or a substantially similar sequence thereof;
• and
• the CDRL1 region comprises the amino acid sequence of SEQ ID NO:
• 4 or a substantially similar sequence thereof;
• the CDRL2 region comprises the amino acid sequence of SEQ ID NO:
• 5 or a substantially similar sequence thereof;
• the CDRL3 region comprises the amino acid sequence of SEQ ID NO:
• 6 or a substantially similar sequence thereof.