Combinatorial therapeutic approach for friedreich's ataxia

A composition for treating or preventing Alzheimer's disease, amyotrophic lateral sclerosis, ataxia, autism spectrum disorder, cerebellar ataxia, fragile X syndrome, frontotemporal dementia, Huntington's disease, Lewy body disease, mitochondrial cardiomyopathy, motor neuron disease, multiple sclerosis, multiple system atrophy, muscular dystrophy, neurodegeneration with brain iron accumulation, Parkinson's disease, progressive supranuclear palsy, spinal muscular atrophy, or spinocerebellar ataxia, the composition comprising quercetin, taurine, and epigallocatechin gallate.

A method for treating a subject suffering from or at risk of developing a disease characterized in involving iron metabolism, mitochondrial dysfunction, and immune pathways, the method comprising administering to the subject a first compound that regulates iron metabolism, a second compound that reduces mitochondrial dysfunction, and a third compound that modulates immune function.