Methods and compositions for suppressing aging-associated clonal hematopoiesis
AssigneeThe Jackson Laboratory
InventorsJennifer Trowbridge, Kira Young, Jennifer SanMiguel, Logan Schwartz
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Abstract
The present disclosure is directed to methods of treating clonal hematopoiesis in a subject thereof, comprising administering to the subject a mitochondria-targeted antioxidant in an amount effective to suppress clonal hematopoiesis in the subject, relative to an untreated control where the mitochondria-targeted antioxidant is a shortened form of the antioxidant ubiquinol with triphenylphosphonium.
Claims20
A method of treating clonal hematopoiesis in a subject in need thereof, comprising:
- administering to the subject a mitochondria-targeted antioxidant in an amount effective to suppress clonal hematopoiesis in the subject, relative to an untreated control.
A method of treating clonal hematopoiesis in a subject in need thereof, comprising:
- administering to the subject a TNF signaling inhibitor in an amount effective to suppress clonal hematopoiesis in the subject, relative to an untreated control.
A method of treating clonal hematopoiesis in a subject in need thereof, comprising:
- administering to the subject a OSM signaling inhibitor in an amount effective to suppress clonal hematopoiesis in the subject, relative to an untreated control.
The method of any one of the preceding claims, wherein the subject is at risk of blood cancer.
The method of any one of the preceding claims, wherein the subject is at risk of cardiovascular disease.
Dependencies are inferred from the claim text.