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US 2025/0011803 A1Published application
Composition and Methods for Producing Tobacco Plants and Products Having Reduced Tobacco-Specific Nitrosamines (TSNAs)
AssigneeAltria Client Services LLC
InventorsChengalrayan KUDITHIPUDI, Dongmei XU, James Strickland
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Abstract
The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.
Claims21
1-45. (canceled)
A modified tobacco plant comprising:
- a reduced level of one or more tobacco-specific nitrosamines (TSNAs);
- an increased level of activity in a polypeptide comprising a sequence at least 90% identical to SEQ ID NO:
- 13 or an increased amount of the polypeptide;
- and
- an increased level of one or more antioxidants;
- wherein the reduced and increased levels are compared to an unmodified control tobacco plant of the same variety when grown under comparable conditions, and wherein the increased level of activity or increased amount of the polypeptide is a result of a genetic modification in the modified tobacco plant.
3 more elements
A modified tobacco plant comprising:
- a reduced level of nitrite;
- an increased level of activity in a polypeptide comprising a sequence at least 90% identical to SEQ ID NO:
- 13 or an increased amount of the polypeptide;
- and
- an increased level of one or more antioxidants;
- wherein the reduced and increased levels are compared to an unmodified control tobacco plant of the same variety when grown under comparable conditions, and wherein the increased level of activity or increased amount of the polypeptide is a result of a genetic modification in the modified tobacco plant.
3 more elements
Dependencies are inferred from the claim text.